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Reference:
J. Eickholt, X. Deng, and J. Cheng. DoBo: Protein Domain Boundary Prediction by
Integrating Evolutionary Signals and Machine Learning. BMC Bioinformatics. 12:43, 2011.
Set a confidence level for your job. A confidence of 80% means that 80 percent of predicted domain boundary sites are likely within 20 residues of a true domain boundary.
Run an additional test on the protein sequence to predict if the protein is multi-domain or single domain.