P45422
multicom
P45422
full_length
P45422
Results of Structure Prediction for Target Name: P45422 ( Click 
)
Domain Boundary prediction ( View )
>P45422: 1-238
| 1-60: |
M | N | N | V | K | L | L | I | A | G | S | A | F | F | A | M | S | A | Q | A | A | D | R | V | S | I | D | V | K | V | T | L | E | A | A | A | C | T | P | I | L | S | N | G | G | V | V | N | F | G | S | H | S | V | N | R | L | S | T | Q |
| 61-119: |
H | Y | T | Q | I | G | T | R | N | I | N | M | T | I | T | C | E | S | A | T | G | I | A | I | T | A | R | D | T | R | M | D | S | M | T | T | G | K | D | S | G | G | Q | S | G | V | K | Y | T | L | N | G | G | G | Y | I | S | Q | T | T |
| 121-179: |
R | L | F | G | L | G | K | T | K | D | N | K | N | I | G | S | Y | A | V | L | I | D | S | N | N | I | S | A | S | N | G | S | Q | T | L | A | V | S | I | A | G | A | D | A | V | I | T | G | Q | K | R | A | W | Q | T | L | T | A | Y | P |
| 181-238: |
L | A | V | D | Q | S | Y | Y | Y | T | F | V | K | P | G | E | T | T | P | T | P | V | T | N | A | I | I | P | L | Q | V | S | A | S | I | A | N | D | L | G | G | S | E | K | I | E | L | D | G | K | A | V | I | S | V | V | Y | L |
| 1-60: |
C | C | H | H | H | H | H | H | H | H | H | H | H | H | H | H | H | H | H | H | C | C | C | C | E | E | E | E | E | E | E | E | E | C | C | C | C | C | C | C | C | C | C | C | C | E | E | E | C | C | E | E | C | H | H | H | C | C | C | C |
| 61-119: |
C | C | C | C | C | C | C | C | E | E | E | E | E | E | E | E | C | C | C | C | E | E | E | E | E | E | E | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C |
| 121-179: |
C | E | E | E | C | C | C | C | C | C | C | C | E | E | E | E | E | E | E | E | E | E | C | C | C | E | E | C | C | C | C | C | C | E | E | E | E | E | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C | C |
| 181-238: |
C | C | C | C | C | C | E | E | E | E | E | E | C | C | C | C | C | C | C | C | C | E | E | E | E | E | E | E | E | E | E | E | E | E | E | H | C | C | C | C | C | C | C | C | E | E | C | C | C | C | E | E | E | E | E | E | E | C |
|
| | H(Helix): 22(9.24%) | E(Strand): 78(32.77%) | C(Coil): 138(57.98%) |
| 1-60: |
E | E | E | B | B | B | B | B | B | B | B | B | B | B | B | B | B | B | B | B | B | E | E | B | E | B | E | B | E | B | E | B | E | B | B | B | B | B | B | E | B | E | E | E | B | E | B | B | B | B | E | B | E | B | E | E | B | E | E | E |
| 61-119: |
E | B | E | E | B | E | E | E | E | B | E | B | B | B | E | B | E | B | E | B | B | B | B | B | B | B | B | B | E | B | E | E | B | B | B | E | E | E | E | E | B | B | E | B | E | B | E | B | E | B | E | E | B | B | B | B | B | E | B | B |
| 121-179: |
B | B | B | B | B | B | B | B | E | E | E | E | E | B | B | B | B | B | B | B | B | B | B | B | E | B | E | B | E | E | E | E | B | B | B | B | B | B | B | B | B | E | E | B | B | B | B | B | E | E | B | B | B | B | E | B | B | B | B | B |
| 181-238: |
B | B | B | E | E | B | B | B | B | B | B | B | E | E | E | E | B | B | B | B | B | B | E | E | B | E | B | E | B | E | B | B | B | B | B | B | E | E | B | E | B | E | E | E | B | E | B | E | B | E | B | B | B | B | B | E | B | E |
|
| | e(Exposed): 86(36.13%) | b(Buried): 152(63.87%) |
| 1-60: |
T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N |
| 61-119: |
N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N |
| 121-179: |
N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N |
| 181-238: |
N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N | N |
|
| | N(Normal): 220(92.44%) | T(Disorder): 18(7.56%) |
Predicted contact map and distance map
|
Predicted distance map
|
|
Predicted contact map
|
Probability to Precision
| Long-Range |
Average probability |
Predicted precision |
| TopL/5 |
0.97 |
96.72 |
| TopL/2 |
0.93 |
96.76 |
Note: The linear model (Average probability vs Predicted precision) was trained on CASP14 dataset
|
Predicted Top 1 Tertiary structure
|
|
|
| Long-Range |
Precision |
| TopL/5 |
29.17 |
| TopL/2 |
33.61 |
| TopL |
33.19 |
| Top2L |
27.31 |
| Alignment |
Number |
| N |
1820 |
| Neff |
721 |
|
Model comparsion
| Model |
TM-score |
| Model 2 |
0.6724 |
| Model 3 |
0.6791 |
| Model 4 |
0.7865 |
| Model 5 |
0.6794 |
| Average |
0.70435 |
Radius Gyration
|
Similar pdbs
| PDB |
TM-score |
| 1w2z |
0.45448 |
| 1qal |
0.45319 |
| 1ksi |
0.45297 |
| 3n9h |
0.45263 |
| 4ev5 |
0.45205 |
|
Note: This is multi-domain structure, check alignments and domain qualities in individual domains!
|
Predicted Top 2 Tertiary structure
|
|
|
| Long-Range |
Precision |
| TopL/5 |
33.33 |
| TopL/2 |
37.82 |
| TopL |
37.82 |
| Top2L |
32.56 |
| Alignment |
Number |
| N |
1820 |
| Neff |
721 |
|
Model comparsion
| Model |
TM-score |
| Model 1 |
0.6724 |
| Model 3 |
0.9436 |
| Model 4 |
0.6949 |
| Model 5 |
0.6548 |
| Average |
0.74143 |
Radius Gyration
|
Similar pdbs
| PDB |
TM-score |
| 6q5u |
0.44358 |
| 3cqo |
0.44206 |
| 5u74 |
0.43719 |
| 6rvd |
0.43605 |
| 5u73 |
0.43109 |
|
Note: This is multi-domain structure, check alignments and domain qualities in individual domains!
|
Predicted Top 3 Tertiary structure
|
|
|
| Long-Range |
Precision |
| TopL/5 |
35.42 |
| TopL/2 |
37.82 |
| TopL |
37.82 |
| Top2L |
31.51 |
| Alignment |
Number |
| N |
1820 |
| Neff |
721 |
|
Model comparsion
| Model |
TM-score |
| Model 1 |
0.6791 |
| Model 2 |
0.9436 |
| Model 4 |
0.7001 |
| Model 5 |
0.6687 |
| Average |
0.74787 |
Radius Gyration
|
Similar pdbs
| PDB |
TM-score |
| 6uox |
0.44400 |
| 5u74 |
0.44385 |
| 6e1h |
0.44382 |
| 3cqo |
0.44290 |
| 5u73 |
0.44198 |
|
Note: This is multi-domain structure, check alignments and domain qualities in individual domains!
|
Predicted Top 4 Tertiary structure
|
|
|
| Long-Range |
Precision |
| TopL/5 |
29.17 |
| TopL/2 |
33.61 |
| TopL |
33.19 |
| Top2L |
27.94 |
| Alignment |
Number |
| N |
1820 |
| Neff |
721 |
|
Model comparsion
| Model |
TM-score |
| Model 1 |
0.7865 |
| Model 2 |
0.6949 |
| Model 3 |
0.7001 |
| Model 5 |
0.6592 |
| Average |
0.71018 |
Radius Gyration
|
Similar pdbs
| PDB |
TM-score |
| 2woh |
0.48171 |
| 6ezz |
0.48155 |
| 1lvn |
0.48148 |
| 1dyu |
0.48139 |
| 2w0q |
0.48125 |
|
Note: This is multi-domain structure, check alignments and domain qualities in individual domains!
|
Predicted Top 5 Tertiary structure
|
|
|
| Long-Range |
Precision |
| TopL/5 |
29.17 |
| TopL/2 |
34.45 |
| TopL |
34.03 |
| Top2L |
28.57 |
| Alignment |
Number |
| N |
1820 |
| Neff |
721 |
|
Model comparsion
| Model |
TM-score |
| Model 1 |
0.6794 |
| Model 2 |
0.6548 |
| Model 3 |
0.6687 |
| Model 4 |
0.6592 |
| Average |
0.66552 |
Radius Gyration
|
Similar pdbs
| PDB |
TM-score |
| 1kfu |
0.42628 |
| 1u5i |
0.42065 |
| 3sqo |
0.41966 |
| 6u2f |
0.41954 |
| 6u3i |
0.41825 |
|
Note: This is multi-domain structure, check alignments and domain qualities in individual domains!
|
References
[1] Hou, J., Wu, T., Cao, R., & Cheng, J. (2019). Protein tertiary structure modeling driven by deep learning and contact distance prediction in CASP13. bioRxiv, 552422.
[2] Li, J., Deng, X., Eickholt, J., & Cheng, J. (2013). Designing and benchmarking the MULTICOM protein structure prediction system. BMC structural biology, 13(1), 2.
[3] Cheng, J., Li, J., Wang, Z., Eickholt, J., & Deng, X. (2012). The MULTICOM toolbox for protein structure prediction. BMC bioinformatics, 13(1), 65.
[4] Wang, Z., Eickholt, J., & Cheng, J. (2010). MULTICOM: a multi-level combination approach to protein structure prediction and its assessments in CASP8. Bioinformatics, 26(7), 882-888.
